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This protein may play a role in processes such as DNA repair, recombination, replication, transcription, and combined DNA functions.[236,237,238,239,240,241,242,243,244] Telomere dysfunction has been associated with premature aging and cancer susceptibility.[245] Other helicases with similar function are altered in other chromosomal instability syndromes, such as BLM in Bloom syndrome and RecQL4 in Rothmund-Thomson syndrome

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In mouse models of colitis, treatment with the PXR activators protected against colitis [18]

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