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Additionally, histone lactylation can activate the transcription of stemness-related genes, maintaining the self-renewal capacity and chemotherapy resistance of liver cancer stem cells [41,42]

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

In addition to cysteine and GSH depletion, our data showed a marked increase in total and mitochondrial ROS following dual inhibition, which was effectively reversed by NAC treatment

Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection