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Revisiting STAT3 signalling in cancer: new and unexpected biological functions

It is known that the 32-kDa precursor proBDNF can be processed endoproteolytically within the pro-domain by the enzyme subtilisin/kexin-isozyme 1 (SKI-1), generating a 28 kDa protein (Seidah et al

In experiments where electrical stimuli were directly applied to the surface of the cerebellar cortex but also at various depths below the surface, John Eccles and a group of pioneering cerebellar electrophysiologists (1966) observed an excitatory response that propagated along the parallel fibers and was flanked on either side by inhibitory responses [309]