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Keywords: Restless legs syndrome, Dopamine agonists, Ropinirole, Pramipexole, Rotigotine, Gabapentin enacarbil, Opioids, Methadone, Augmentation, Anticonvulsants Introduction Restless legs syndrome (RLS) is a neurological sensorimotor disorder that is diagnosed based on 4 essential clinical criteria that were established by the International RLS Study Group in 2003 [1]

Healthcare providers should maintain open communication about all treatments patients are using and provide evidence-based guidance prioritizing interventions with established safety and efficacy profiles

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