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Researches indicate that the risk of all-cause mortality in individuals with T2DM is 1.8 times higher than in those without T2DM, and the medical costs associated with T2DM are reported to be 2.3 times greater than those of individuals without T2DM [1, 2]

FASEB J 29(6):25662582 Karolczak K, Watala C (2019) The mystery behind the pineal gland: melatonin affects the metabolism of cholesterol

Global changes in interleukin-6-dependent gene expression patterns in mouse livers after partial hepatectomy

Moreover, owing to its significant intratumoral heterogeneity, the positive responses observed in a small cluster of patients to immunotherapies or other treatment modalities cannot be extrapolated to represent the overall treatment sensitivity of GBM