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Accumulating evidence shows that activation of Nrf2 upregulates key genes involved in redox homeostasis, including SLC7A11, glutathione synthetase, and glucose-6-phosphate dehydrogenase, thereby increasing the production of reduced cofactors such as NADPH, GSH, and CoQ10, which collectively enhance cellular antioxidant capacity and counteract disease-associated oxidative stress (277)

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Our protein-tagging approach was analogous to existing split-FP methods developed for human cells [Kamiyama 2016, Leonetti 2016] and C