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10.1016/j.celrep.2023.112986 105 KoeckT.OlssonA

95% CI: 0.0020.37

114 In the meantime, chimeric antigen receptor (CAR)-modified immune cells and oncolytic viruses are also under investigation

Representative strategies targeting this axis, from glycolytic enzyme inhibitors to lactylation modulators, have advanced from preclinical validation to early-phase clinical trials, with select agents demonstrated preliminary safety and target engagement