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Heatmap generation Heatmap indicating transcript abundance and expression pattern was generated using the HEATMAP hierarchical clustering web tool ( The log2 fold-change values of relative expression levels (the 2 (Ct) value) were used to construct the heatmap

The current study addressed these limitations by testing a noninvasive nasal GSH repletion strategy, and measuring CNS uptake via proton magnetic resonance spectroscopy ( 1 H-MRS)