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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Lioudyno VI, Tsymbalova EA, Chernyavskaya EA, Scripchenko EY, Bisaga GN, Dmitriev AV, Abdurasulova IN

In human gingival mesenchymal stem cells, Epitalon regulates gene expression and protein synthesis: it preferentially binds to histones H1/6 and H1/3 at sites that interact with DNA, thus suggesting that binding to histones may be an additional mechanism for enhancing the expression of genes that regulate neuronal differentiation and protein synthesis [10]

Recently heme and ferrylHb were identified as activators of the NLRP3 inflammasome leading to processing and secretion of active IL-1 in LPS-primed macrophages (81, 82)