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Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma

During host cell infection, CoVs trigger an imbalance involving increased ROS production and reduced antioxidant host responses, thereby leading to increased redox stress, reduced antiviral host responses, and increased virus-induced inflammation and apoptosis, ultimately causing cell and tissue damage and end-organ disease 3

Hecker, S

It is worth noting that GPX4 is the only known mammalian enzyme that can directly catalyze the reduction of hydroperoxides in phospholipids to effectively suppress ferroptosis (9)