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The first two stages are integrated into the methionine cycle, while the subsequent two phases are integral components of the transsulfuration pathway

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Moreover, recently identified 4-HNE-modified proteins in OA chondrocytes may provide a unique opportunity to investigate how chondrocytes adapt to oxidative stress and lipid peroxidation

doi: 10.3389/fped.2025.1514722 Received 21 October 2024 Accepted 03 January 2025 Published 27 January 2025 Volume 13 - 2025 Edited by Sachith Mettananda, University of Kelaniya, Sri Lanka Reviewed by Nishant Chakravorty, Indian Institute of Technology Kharagpur, India J.W