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Similarly, in OA, this mechanism may contribute to pathological processes, such as aberrant subchondral bone remodeling and osteophyte formation, by amplifying the bone resorption-formation imbalance, although its deeper mechanisms require further investigation

In the presence of OS in adipocytes, anti-inflammatory adiponectin level falls [118, 119], while pro-inflammatory adipocytokines concentration rises [115, 120, 121]

Therefore, exerting the role of the antioxidant defense system can also help promote the ferroptosis process of GBM

Laboratory ranges can vary but many will consider under 160 pmol/L (216 ng/l, pg/L) to be a cut-off for confirming deficiency