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CI supervised the work and wrote and revised the manuscript

Ischemic stroke was obtained from MEGASTROKE consortium (34,217 cases and 406,111 controls) [25], the UK Biobank (7961 cases and 384,003 controls), and Finngen Biobank (10,551 cases and 208,241 controls) [26]

Its prevalence is between 15% and 85% of patients with ALS [84]