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Immunohistochemistry revealed elevated expression levels of MAPL, SUMO1 and cleaved caspase-3 in the degenerated IVD tissues, with the highest levels observed in the IVDD + AAV-MAPL group

Reactive astrocytes interact with microglia/macrophages and initiate the formation of the scar-border via secretion of extracellular matrix proteins, such as laminin, fibronectin and chondroitin sulfate proteoglycans (CSPGs) (Sofroniew, 2009

Synaptogenesis and Dendritic Spine Formation Independent of the specific HGF-binding biochemistry, Dihexa treatment of cultured rat hippocampal neurons was reported to increase dendritic spine density roughly three-fold over 5 days (approximately 41 spines per 50 um of dendrite with Dihexa versus 15 with vehicle), with newly formed spines containing normal synaptic machinery (VGLUT1, synapsin, PSD-95) and functional AMPA-receptor-mediated activity