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On CT, MSs generally appear isodense or slightly hyperdense and may contain calcifications

However, a notable side effect was observed: MT-II-treated normal C57BL/6J mice exhibited significant weight loss, with their average weight decreasing from a baseline of 30.9 1.4 grams to 26.5 1.7 grams after the 14-day treatment course, a change not seen in vehicle-treated controls

Throughout the study, safety assessments included physical examinations, vital sign measurements, electrocardiograms, laboratory testing, adverse event monitoring, and the administration of the Beck Scale for Suicidal Ideation

This structured approach improves both safety and consistency