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Abbreviations ACC: Acetyl-CoA Carboxylase ACLY: ATP-Citrate Lyase ADP: Adenosine Diphosphate AKT: Protein Kinase B AMPK: AMP-Activated Protein Kinase ATP: Adenosine Triphosphate ATF4 / ATF5: Activating Transcription Factor 4 / 5 CAF: Cancer-Associated Fibroblast cGAS: Cyclic GMPAMP Synthase cGAMP: Cyclic GMPAMP CHOP: C/EBP Homologous Protein CNV: Copy Number Variation CO1CO3: Cytochrome c Oxidase Subunit IIII CPT1: Carnitine Palmitoyltransferase 1 CTC: Circulating Tumor Cell CYB: Cytochrome b DAMPs: Damage-Associated Molecular Patterns ddPCR: Droplet Digital PCR DHODH: Dihydroorotate Dehydrogenase D-loop: Displacement Loop ETC: Electron Transport Chain EMT: EpithelialMesenchymal Transition EV: Extracellular Vesicle FAO: Fatty Acid Oxidation FASN: Fatty Acid Synthase GAP43: Growth-Associated Protein 43 GJC: Gap Junction Channel GLUT1: Glucose Transporter 1 GPx: Glutathione Peroxidase GSH: Glutathione HIF-1: Hypoxia-Inducible Factor 1-alpha IL-6 / IL-2: Interleukin 6 / 2 ISR: Integrated Stress Response JNK: c-Jun N-terminal Kinase LDHA: Lactate Dehydrogenase A MAPK: Mitogen-Activated Protein Kinase MFN2: Mitofusin 2 MPC: Mitochondrial Pyruvate Carrier MSC: Mesenchymal Stem Cell mtDNA: Mitochondrial DNA M-Sec: Tumor Necrosis Factor Alpha-Induced Protein 2 mTOR: Mechanistic Target of Rapamycin ND1ND6: NADH Dehydrogenase Subunits 16 NF-B: Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells NRF2: Nuclear Factor Erythroid 2Related Factor 2 NUMT: Nuclear Mitochondrial DNA Segment OPA1: Optic Atrophy 1 OXPHOS: Oxidative Phosphorylation PD-L1: Programmed Death-Ligand 1 PI3K: Phosphoinositide 3-Kinase ROS: Reactive Oxygen Species rRNA: Ribosomal RNA SOD2: Superoxide Dismutase 2 SNV: Single Nucleotide Variant STING: Stimulator of Interferon Genes SREBP1: Sterol Regulatory ElementBinding Protein 1 TBK1: TANK-Binding Kinase 1 TCA: Tricarboxylic Acid Cycle TCGA: The Cancer Genome Atlas TIL: Tumor-Infiltrating Lymphocyte TNT: Tunneling Nanotube TPP: Triphenylphosphonium tRNA: Transfer RNA USP30: Ubiquitin-Specific Protease 30 VEGF: Vascular Endothelial Growth Factor WGS: Whole Genome Sequencing References Chung CY, Valdebenito GE, Chacko AR, Duchen MR

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ALA is frequently referred to as the "universal antioxidant." Furthermore, ALA features a unique dithiolane ring that allows it to transition freely between its oxidized state (ALA) and its reduced state, known as dihydrolipoic acid (DHLA)

The binding of -syn to GAPDH with partially oxidized active site cysteines leads to the inactivation of the enzyme