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An imbalance (excess/reduction) of K+, Na+-channels (encoded by the SCN5A gene), Ca2+, as well as ion channel disturbances, together with various DNA and mitochondrial alterations represent the most important triggers in initiation and abnormal nervous conduction, thus leading to arrhythmogenesis

Spermine oxidase (SMOX) is activated in H

When this happens, the gradual buildup of dysfunctional mitochondria can lead to increased inflammation, which is associated with a higher risk of chronic diseases, like cancer or dementia.8 15 So, if urolithin A can kickstart mitophagy, then it may lower your risk for chronic disease, increasing your healthspan and your lifespan

Nat Med (2017) 23(1):1207