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A possible synergistic effect of MTHFR C677T polymorphism on homocysteine level variations increased risk for ischemic stroke

A 2008 study on muscle endurance and power in college varsity football players showed essentially no such benefit, while a small trial in cross-country runners three years later found no performance-enhancing benefits and one result that actually contradicted the claim made for the patch

Crit Rev Food Sci Nutr 38:315330 Gl H, Turak M, Gl M, Mazlumolu S, Sakagami H, Glin , Supuran CT (2019) New phenolic Mannich bases with piperazines and their bioactivities