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It produces proinflammatory cytokines and chemokines like interleukin (IL)-12 and tumor necrosis factor alpha (TNF), induces further inflammation and IFN release, and attracts neutrophils, natural killer (NK) cells, and lymphocytes to the site of infection (135)

While numerous studies have demonstrated encouraging preclinical outcomes using polyphenols such as curcumin, quercetin, resveratrol, and betulin encapsulated in lipid- or polymer-based nanocarriers, their translational promise remains highly variable

Recent studies have indicated that VacA, a key toxin of inducing autophagy and apoptosis, can be considered as a marker to predict the risk of gastric carcinogenesis in animal models (Carlosama-Rosero et al., 2021