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Freezing reconstituted IGF-1 LR3 in a multi-dose vial is not recommended because freeze-thaw cycles cause ice crystal formation that mechanically denatures the peptide structure, reducing potency by 3050% per cycle

on the other hand, it also activates autophagy induction (the final degradation step of this V-ATPase dysfunction-induced autophagy still requires the remaining hydrolytic activities)