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Immunofluorescent assay (IFA) of Ki67 and LGR5 further indicated a loss of LGR5 + ISCs in the crypt compartments of non-treated Veh controls and restored by IPA treatment at D7 when exposed to DSS, whereas no significant differences in immunostaining were seen between IPA- and Veh-treated mice at D0 (Fig

Introduction Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults with a prevalence of 35/100,000 in Europe and the United States (Brown and Al-Chalabi, 2017)