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However, current research still exhibits notable limitations, including the unidentified nature of most active components (such as specific miRNAs or proteins), a reliance on ex vivo or murine models without clinical validation, insufficient long-term safety and pharmacokinetic data, and a lack of standardization in administration methods and dosages

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R001 treatment specifically modulates NADPH and GSH levels, and mitochondrial respiration in triple-negative breast cancer cells The biochemical functions of G6PD lead to the generation of NADPH, which provides a reducing equivalent for anabolic reactions and is also required for cellular redox balance, including maintaining cellular GSH levels [36], an anti-oxidant

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