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For ZnC 59 , the HOMO is at 4.45 eV and the LUMO at 4.09 eV, leading to a very small HOMO-LUMO gap of 0.36 eV, indicating high reactivity

Also advancing an amylin candidate is AstraZeneca, which is positioning its AZD6234 as a potential alternative or complement to GLP-1 therapies

AS-IV treatment was found to significantly ameliorate the increase of ROS in the cortex and hippocampal CA1 of T2DM mice, decrease MDA levels, increase SOD activity in T2DM mice, and the Nrf2/Keap1/HO1/NQO1 pathway is the main pathway by which AS-IV reduces oxidative stress after T2DM, which in turn reduces cognitive impairment in T2DM mice (56)

The combination activates cellular regeneration through multiple pathways simultaneously, exceeding what either compound achieves individually