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Neuroprotective Effect of the LRRK2 kinase inhibitor PF-06447475 in human nerve-like differentiated cells exposed to oxidative stress stimuli: Implications for Parkinsons disease

Concurrently, sulforaphane robustly activates Nrf2-dependent cytoprotective programs, including induction of HO-1 and phase II antioxidant enzymes, resulting in attenuation of oxidative stress, preservation of mitochondrial integrity, and improvement of renal microvascular and tubular function in ischemic and inflammatory AKI models (Yoon et al

4.3 Liver cancer Liver due to its high metabolic activity tends to build up multiple ROS, which can be another reason for inflammation and cancer other than genetic factors and exposure to foreign substances (Liou and Storz, 2010)