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For example, the antidepressant paraoxetine increased the risk of heart defects by 45%, heart valve defects by 39%, muscle and skeletal defects by 92%, and early fusing of the skull plates up by nearly 300% (a very dangerous condition that restricts brain growth)

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Coverslip staining was performed as previously described (Vermilyea et al

Furthermore, the role of SLC25A33-mediated mtDNA synthesis and mtROS production in facilitating mtDNA release during macrophage polarization and the dysregulated inflammatory response warrants further investigation