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Venomic Adaptations Of Prey Specialised Spiders

In this binding mode, hydrogen bonds of Tyr111 and Gln207 to the carbonyl oxygen atoms of 4HNE, NE, and EA could orient the substrates and enhance their electrophilicity to promote conjugation with glutathione

The hypothesis suggests that PCs activate the S100A11/RAGE/PPAR signaling pathway, resulting in reduced RAGE expression and alleviation of cardiac fibrosis triggered by AGEs in type 2 diabetic rats (Luan et al., 2014)