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When combined, these overlapping side effect profiles may worsen GI tolerability, particularly during the dose escalation phase when tirzepatide GI effects are already at their peak

[1] Ashok Agarwal, et al

Preclinical findings showed that simvastatin can reduce the activation of astrocytes and microglia and inhibit the release of pro-inflammatory cytokines in C6 glioma cells subjected to the effects of LPS (Zheng et al., 2018)