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First, activation free energies (G ) for the addition reactions between compound 1 and model thiolates (MeS - ) and amines (MeNH 2 ) are predicted by DFT calculations (Fig

Assessment of recent doses taken, including any recent dose reductions, is necessary to determine if a subtherapeutic INR is owing to insufficient warfarin intake, in which case an increase in dosage will be required to return the INR into the prescribed range