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Treatment is directed at reducing the frequency of exacerbations, improving quality of life and preventing disease progression

Blots were washed three times with 1% (w/v) non-fat dry milk TTBS and incubated with the secondary antibody (rabbit for Id2 and mouse for tubulin) diluted in 1% non-fat dry milk TTBS conjugated to horseradish peroxidase (Santa Cruz Biotechnology, CA, USA) for 60 min at room temperature

In contrast, we found that these metabolomic alterations led to a reduction in the plasma level of different metabolites including uridine, thymine, carnosine, theophylline, aspartate, taurine, serine, glutamate, tryptophan, arginine, and 53 other metabolites in the acute patients compared to HCs ( Supplementary Figures 6A, B )