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Occasionally used off-label for fibromyalgia, restless leg syndrome, anxiety Pharmacokinetics Absorption: Oral, dose-dependent bioavailability (decreases at higher doses) Distribution: Not highly protein-bound Metabolism: Minimal hepatic metabolism Excretion: Renal (adjust dose in renal impairment) Half-life: 57 hours Adverse Effects Common: dizziness, somnolence, ataxia, fatigue Less common: peripheral edema, tremor, blurred vision Rare: hypersensitivity reactions, mood changes Pregnancy / Lactation Pregnancy: Limited human data

The adaptive remodeling of endothelial glycocalyx in response to fluid shear stress

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Documents from the Texas Medical Board show that Cleveland passed out and was taken to a hospital, where she arrived at 12:17 p.m