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ACS Chem Neurosci 15:130 Ter Borg S, Verlaan S, Hemsworth J, Mijnarends DM, Schols JM, Luiking YC, De Groot LC (2015) Micronutrient intakes and potential inadequacies of community-dwelling older adults: a systematic review

Much of the above was considered purely theoretical, based on observation of human and animal behavior but without direct biologic correlation until 2019 when Professor Connor Liston published a groundbreaking paper in Science , demonstrating the atrophy of dendritic spines on brain cells in the presence of high levels of NMDA activity

The effects of ethanol on the heart: alcoholic cardiomyopathy

In addition, leucine protects against macrophage foam cell formation by inhibiting lipid biosynthesis, promoting cholesterol efflux and enhancing mitochondrial respiration (191, 197, 214, 215)