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In parallel, growth hormonerelated pathways are also linked to fat metabolism and body composition regulation

GSH is the major cellular antioxidant which maintaining redox homeostasis from the following two aspects: bind to ferrous iron in the labile iron pool (LIP) to prevent the iron-dependent oxidization (Hider and Kong, 2011) and as the substrate of GPX4-mediate lipid detoxification (Friedmann Angeli et al., 2014

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High circulating ADM was strongly associated with disease severity, organ failure, vasopressor need, and 30-day mortality, highlighting its value as both a biomarker and predictor of outcome in septic patients (Lundberg et al., 2020)