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Neuron 85(6):11931199 Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W et al (2017) A review of sleep disorders and melatonin

Trial subjects reported improved skin hydration within 1-2 weeks, noticeable texture and firmness improvements at 4-8 weeks, and reduced fine lines with better skin resilience at 8-12+ weeks

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Metabolism plays an important role for AS toxicity