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Total protein levels of Bcl-2 were significantly decreased (77.6 6.1%) but the total protein levels of Bax and cleaved caspase-3 were significantly increased (598.2 69% and 291.4 23.5%, respectively) in the livers of APAP-treated rats as compared to control rats ( Fig

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Konopleva M, Tsao T, Ruvolo P, Stiouf I, Estrov Z, Leysath CE, Zhao S, Harris D, Chang S, Jackson CE, Munsell M, Suh N, Gribble G, Honda T, May WS, Sporn MB, Andreeff M