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250 The tumor microenvironment may be one of the culprits for therapeutic resistance, and researchers have found that maintaining or inhibiting the expression of certain molecules in the tumor microenvironment is a pathway for overcoming drug resistance

Elderly individuals may require maintenance supplementation

Pharmacol Res 66:199206 Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM (2009) Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential