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Pro-apoptotic markers, including caspase-3, Bax, and p53, are upregulated by cyclosporin treatment, while anti-apoptotic proteins, such as Bcl-2, have been decreased (El-Sherbeeny & Nader 2016

DZN administered at 4.1 mg/kg to mice for 4 weeks increased testosterone levels, but it reduced testosterone levels when administered at 8.2 mg/kg [13]