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Deviation of the observed pathway score from the null distribution was quantified by the fraction of times that the simulated score was more extreme than the observed score

Pigmentation may fade as skin cells turn over, but individual changes vary and UV exposure can affect the apparent result

they help recalibrate it, teaching your body to mount an appropriate response and then shut it off when the job is done

It's the gap between aligning a peptide protocol with the biology it was designed to exploit versus forcing it to work against circadian receptor rhythms that have been conserved across 200 million years of mammalian evolution