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In contrast, another study found no difference in micronucleus levels between patients who received MTX treatment and those who did not, suggesting that the generation of micronuclei was associated with RA itself (47)

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Notably, the hypoxic environment of the periodontal pocket further synergistically upregulates TFRC by stabilizing hypoxia-inducible factor-1 (HIF-1) and enhancing the endocytosis of transferrin-bound ferric iron (Fe 3+ ) (11)