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VRK2 overexpression could suppress the increase of shrunken mitochondria and lipid ROS induced by TBHP, while BFA treatment abolished VRK2-mediated alterations (Fig

Current evidence indicates that, across multiple models, 4-HNE activates inflammasomes, promotes calcium overload, impairs autophagylysosome flux, and interferes with transcriptional regulation and mRNA stability by modifying nuclear or RNA-binding proteins (Xiao Liang, 2024

Dose-dependent vasorelaxant effect of GSNO in coronary artery rings Figure 4a shows a representative schematic of the isolation of the septal branch of the left coronary artery and its mounting as a vascular ring in a wire myograph, in which a force transducer records changes in isometric tension over time (Fig