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Furthermore, it should be noted that three recently discovered dimeric indole alkaloids namely 17-deacetoxycyclovinblastine, 14,15-didehydrocyclovinblastine, and 17-deacetoxyvinamidine along with five established compounds (vinamidine, leurosine, catharine, cycloleurosine, and leurosidine) exhibited in vitro viability inhibition against the human breast cancer cell line MDA-MB-231 with an inhibitory concentration ranging from 0.73 to 10.67 M (44)

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Marin, I

Notably, COX-2 and PGE2 promote the survival of different pathogens in host cells, induce the replication and dissemination of pathogens, and downregulate the immune response (93, 94)