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Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising translational tool to target human aging

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Summary 5-Amino-1MQ (5 amino 1mq) has been examined in laboratory studies as a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT)

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