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How IV Ozone Therapy Works (Major Autohaemotherapy) The gold-standard method used in clinics is Major Autohaemotherapy (MAH): A small volume of blood is drawn It is exposed to a precise oxygenozone mixture The treated blood is re-infused into the body This process creates a controlled, temporary oxidative stimulus, which: Activates antioxidant enzymes Improves oxygen delivery to tissues Increases cellular energy (ATP production) Stimulates immune signalling pathways Clinical literature describes this as a form of controlled oxidative stress that triggers beneficial biological responses when administered correctly

In a study carried out in THP 1 human macrophages, metformin blunted foam cell formation induced by palmitic acid (Song et al., 2010)

Another important biochemical pathway for maintaining redox homeostasis is the thioredoxin (TRX)-thioredoxin reductase (TrxR) system [1]

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