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The recommended daily intake for adults varies depending on age and gender: 35 mg for men and 25 mg for women aged 50 years or younger, and 30 mg and 20 mg, respectively for older men and women ( Chromium deficiency may present as peripheral neuropathy, insulin resistance, and weight loss

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Using spectrophotometry Gilles Venturini reported a roughly 40% decrease of copper (Cu 2+ ) in the brain of Swiss mice treated with cuprizone for 34 weeks [28], while others reported an increase in copper after 1 week (Cu 2+ and Cu + ) [90] and 3, 6 and, 9 months (total free and bound) [91] following cuprizone treatment

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