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Description

Alvarez et al., 2013

S6K1 has the ability to phosphorylate the insulin receptor and reduce its sensitivity to insulin in a negative feedback loop on mTORC1 signaling

This compound suppressed pulmonary colonization by B16-F10 murine melanoma cells, which are characterized by an overactive HGF/Met system

The clinical judgment of the treating physician should guide the management plan of each patient based on individual benefit/risk assessment [see Adverse Reactions (6.1)]