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280 A preliminary study included five female monkeys with simian acquired immunodeficiency syndrome, caused by inoculation with a virus that is closely related to HIV, called simian immunodeficiency virus

Research efforts are also focused on understanding how variations in experimental design, concentration, and molecular stability may affect compound behavior across different in vitro systems

Figure 1 shows the PRISMA flowchart

Two samples of patients (aged 1855 years and fluent in English) were recruited at each site, from populations representing two phases of illness: a minimally treated group (less than 12 weeks) with recent onset of illness of less than 5 years (Recent group) and a group with established illness of at least 10 years duration (Established group)