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Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

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The altered homeostatic incretin levels in PAR2-G37I or PAR2-R38E versus WT mice were not caused by apparent changes in metabolism, as no significant differences in food and fluid intake, energy expenditure, respiratory exchange ratio, or locomotor activity were observed in indirect calorimetry (Supplemental Figure 2, A and B)

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Epidemiological studies, as reported by Agency for Toxic Substances and Disease Registry (ATSDR) (5), indicate that over 5 million people are exposed to dangerous metals like Cd annually, known for their toxic properties and cumulative effects (18)

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