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However, excessive sebum production is shown to be a significant contributor to the pathophysiology of Acne vulgaris [130,131,132]

12:e0188840

The intracellular glutamate concentration is nearly 10-fold higher than the Km value, but intracellular cysteine concentrations approximate the apparent Km value [10] , indicating that cysteine may be a limiting substrate for GCL

1c, this substrate-induced closure likely primes the transporter for ATP binding by aligning optimally the Walker A and signature motifs of opposing NBDs