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The combination of three methyl donors - SAM, folate, betaine (Figure 2) - alleviated alcoholic liver injury, while at the same time lowering the elevated SAM / SAH ratio and homocysteine level (114), but the aforesaid evidence also points to the critical importance of ascorbic acid in protecting the exocrine pancreas, as shown by its ameliorating effect in animal models of mild and severe pancreatitis (30)