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Patients with sufficient vitamin D had lower MMP1 and MMP13 levels compared to those with insufficiency of vitamin D, suggesting that vitamin D promotes anti-resorption by upregulating antioxidant enzymes like PON-1 and TAC and downregulating MMPs like MMP1 and MMP13, to protect against cartilage degradation in OA

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Future directions in nanotechnology-enabled RA therapies should focus on the development of biosafe, biomimetic nanocarriers that enhance targeting precision and minimize safety risks