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Clinical Recognition and Therapeutic Development (1980Present) The shift from biochemical curiosity to clinical intervention accelerated in the 1980s when Dean Jones at Emory University demonstrated that glutathione status could be manipulated therapeutically using N-acetylcysteine (NAC), a precursor that bypasses the rate-limiting step in glutathione synthesis

Furthermore, we confirmed that higher GLO-1 expression was significantly associated with reduced DFS in HNSC, SARC, and LIHC, but not in KIRC or COAD ( Figure 2B )

10.3390/molecules25184145 42 FanL.ZhangX.HuangY.ZhangB.LiW.ShiQ.et al (2023)

Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS